Journal: eLife

Article Title: Endophilin A1 facilitates organization of the GABAergic postsynaptic machinery to maintain excitation-inhibition balance

doi: 10.7554/eLife.102792

Figure Lengend Snippet: ( A ) Endophilin A1 directly interacts with the inhibitory postsynaptic scaffold protein gephyrin to promote organization of iPSD and synaptic recruitment/stabilization of the GABA A Rs via its plasma membrane association and actin polymerization-promoting activities. ( B ) Loss of endophilin A1 impairs inhibitory synaptic neurotransmission and disrupts the balance of excitatory/inhibitory activities in the neural circuits, leading to enhanced epileptic seizure susceptibility.

Article Snippet: At the excitatory synapse, the plasma membrane-associated endophilin A1 regulates the morphogenesis, maturation, and structural plasticity of dendritic spines by promoting branched actin polymerization underneath the postsynaptic membrane via its interaction with the cytoskeleton regulator p140Cap ( ; ; ).

Techniques: Clinical Proteomics, Membrane